Item 2: PLANNED TREATMENT

Cancer in general is treated in several ways, such as surgery, chemotherapy, and radiation to name a few. Lymphomas are best treated by chemotherapy. There are two possible chemotherapy routes types of chemical recipes) for treating this specific lymphoma: the conventional (“CHOP”) formula and the trial routine (“RFND”). Note that the four-letter acronym represents the four chemicals used in each chemo recipe. We have at this time chosen the trial approach. Administering a trial treatment means the use of new experimental chemicals that are being tested. In this case, the particular RFND formula we are using has been used by patients for five years. One of the advantages of this formula is (1.) that it contains a medicine, Zevalin, which adds strength at destroying the cancer and (2.) that a good portion of the cost of the two medicines, Zevalin and Riluxan, is taken care of by the trial sponsor. Most of the chemicals will be administered every month, 4 continuous days the first month and three continuous days the other three months. Treatment from these first four months most of the time provides the R, F, N, and D chemicals. Then a final kick after those four weeks is the major part of the trial drug Zevalin. It is an orally-administered pill that that is trained to follow the Riluxan chemical, which in turn is trained to follow the B-cells (which are carrying the lymphoma). It provides assurance that the lymphoma stays away for some time.